For instance, in the case of K+ depletion, DCT cells proliferate to enhance the surface of Na+ reabsorption [11] and hypokalemia induces NCC activation through a pathway that involves the basolateral K+ channel Kir4.1/Kir5.1 and CLC‐Kb [12, 13, 14]. Here, SLC12A3 is linked to Hypokalemia.