ADAM17 and diabetes mellitus: We created cardiomyocyte-specific knockout of ADAM17 (A17α-MHCKO) mice with or without diabetes and assessed left ventricular dimension, function, pathology and molecular biology in four groups of mice: ADAM17fl/fl control, A17α-MHCKO control, ADAM17fl/fl diabetic and A17α-MHCKO diabetic mice.