We examined mRNA levels of 12 substrates of ADAM17 including TNF-α, TNF-αRI, TNF-αRII, IL-6, IL-6R, ALCAM, AREG, ERBB4, TGF-α, ICAM, VCAM, and ACE2 in a mouse model of DCM and found that only ACE2 mRNA level showed a significant change in the DCM mice than the control mice, suggesting that ACE2 plays a central role in the pathogenesis of DCM. This evidence concerns the gene AREG and familial dilated cardiomyopathy.