Previous reports have identified various risk factors for developing AKI associated with SMX/TMP, such as the presence of hypertension, diabetes, low baseline estimated glomerular filtration rate (eGFR), cardiac disorders, administration of high-dose SMX/TMP, and concomitant use of renin-angiotensin system blockers, potassium-sparing diuretics, and potassium supplements [8, 9, 12, 13]. The gene discussed is REN; the disease is Hypertension.