Previous reports indicated hypertension, diabetes, low baseline eGFR, cardiac disorders, high-dose SMX/TMP, concomitant use of renin-angiotensin system blockers, potassium-sparing diuretics, and potassium supplements are risk factors for AKI associated with SMX/TMP [8, 9, 12, 13]. This evidence concerns the gene REN and Hypertension.