However, knockdown of TRIM18 significantly increased production of IFN-β (Fig. 1e–h) and IFN-α (Additional file 2: Fig. S2b–e) by THP-1 macrophages compared to cells treated with control shRNA after infection with RNA viruses Flu PR8 and CVB3 and DNA virus HSV-1 (Fig. 1e–h, Additional file 2: Fig. S2b–e). This evidence concerns the gene IFNA1 and infection.