MID1 and viral encephalitis: Therefore, we investigated the role of TRIM18 in antiviral immune response in human THP1 macrophages by infection with two RNA viruses coxsackievirus B3 (CVB3, a RNA virus targeting heart for inducing viral myocarditis) and influenza A virus PR8 strain (Flu PR8, a RNA virus targeting lung to induce viral pneumonia), and two DNA viruses including herpes simplex virus type I (HSV-1, a DNA virus targeting brain for inducing viral encephalitis) and human adenovirus (a DNA virus targeting lung for viral pneumonia).