As expected, knockdown of the key adaptor MAVS abrogated the production of IFN-β and IFN-α in THP-1 macrophages in response to RNA viruses Flu PR8 and CVB3 (Fig. 1e, f, Additional file 2: Fig. S2b, c), but not to DNA viruses HSV-1 and adenovirus (Fig. 1g, h, Additional file 2: Fig. S2d, e), while STING knockdown led to significant reduction of IFN-β and IFN-α production in THP1 macrophages after infection with DNA viruses HSV-1 and adenovirus (Fig. 1g, h, Additional file 2: Fig. S2d, e), but not with RNA viruses Flu PR8 and CVB3 (Fig. 1e, f, Additional file 2: Fig. S2b, c). This evidence concerns the gene IFNB1 and infection.