According to internal and external validations, the risk model composed of C5AR2, CD96, CSF3R, FBXW10, FCAR, GHR, IL10, MEFV, OLR1, PGLYRP3, RASGRP4, S100A12, T cells CD8, Macrophages M1 and Eosinophils was stable and effective to predict BLCA patients’ prognosis. Here, RASGRP4 is linked to bladder transitional cell carcinoma.