Although the use of priming and maintenance dose of magrolimab helped reduce anaemia as observed in the first clinical trials, the recent halt on the magrolimab ENHANCE trials in AML/MDS patients highlights the pivotal need to develop strategies that further mitigate toxicity in order to unlock the immune (re)activation potential of CD47‐SIRPα therapy. This evidence concerns the gene CD47 and myelodysplastic syndrome.