IL6 and neoplasm: Hyperthermia dilates tumor blood vessels and increases the perfusion in TME.Hyperthermia significantly increases the proportion of mature DC subtypes (CD11c+, CD80+, CD86+).Hyperthermia causes more monocytes and DCs to be recruited and infiltrated.Hyperthermia increases the CD8+T number in TME.Hyperthermia increases the expression of IFN‐γ, IL‐6, IL‐12, and TNF‐α.