However, mutated tumor cells can increase the expression of some proteins, such as the up‐regulation of PD‐L1 expression, which inhibits the killing effect of cytotoxic T‐lymphocyte by promoting its binding with PD‐1, thus resulting in “immune escape.”36 Based on the above mechanisms, ICIs aim to relieve part of the immunosuppressive signaling pathway and restore the vigor of immune cells.37 This evidence concerns the gene CD274 and neoplasm.