TP53 and metastatic malignant neoplasm in the lymph nodes: Indeed, in contrast to STAT1 (Figure 1C and Figure S1C), TP53 level is significantly reduced in PCa patients with higher grade (Figure S1G) or lymph node metastasis (Figure S1H), and inversely correlated with STAT1 level based on TCGA PCa dataset (Figure S1I).