Based on IFIT5 expression profile in several PCa lines (Figure S3G), IFIT5 expression vector was transfected into either LNCaP or 22Rv1 cells (Figure S3H) and the result indicated that IFIT5 significantly facilitates the number and size of prostasphere formation of both cells (Figure 3E,F). Here, IFIT5 is linked to posterior cortical atrophy.