B3GNT6 was identified as IGF2BP2 target in an m6A manner, and our research verified its oncogenic role in PC, considering that B3GNT6 is an essential enzyme for the synthesis of core 3 O‐glycan48 and to reduce malignant biological characteristics in colon, but was upregulated and a favorable prognostic factor in PC,49 we believed m6A played an essential role in glucose metabolism. This evidence concerns the gene B3GNT6 and pachyonychia congenita.