Next, the functional role and underlying intestinal epithelial repair mechanisms of CS in colitis were elucidated using dextran sulfate sodium (DSS)-challenged intestinal epithelial cell-specific Sult2b1 deletion mice (Sult2b1∆IEC) and littermate control Sult2b1f/f mice that were fed a diet supplemented with CS or cholesterol. Here, SULT2B1 is linked to colitis.