Under the action of allergens in the skin system, numerous inflammation-mediated factors, such as TNF-α, IL1β, and IL-4, are secreted during epidermal keratinization, all of which interact with each other in the pathogenesis of eczema, thus influencing the development and prognosis of the disease [20, 21]. The gene discussed is IL4; the disease is Eczematoid dermatitis.