Light and moderate intensity treadmill running for 4 months from the presymptomatic stage in Otsuka-Long-Evans-Tokushima fatty (OLETF) rats (a T2DM model) normalized MCT2, glycogen, and BDNF levels, accompanied by the improvement of hippocampal-dependent memory dysfunction, suggest that exercise can prevent the progression of T2DM-relative cognitive decline by targeting hippocampal lactate-transport [73]. The gene discussed is BDNF; the disease is type 2 diabetes mellitus.