Mice with long-term ketamine administration showed dose-dependent learning and memory impairment as well as lower hippocampal MCT1 and MCT4 membrane protein levels and higher cytoplasmic protein levels; both MCT2 protein and mRNA levels in the hippocampus were significantly increased, suggesting that long-term ketamine administration-induced cognitive impairment may be related to abnormal expression of MCTs in the hippocampus [43]. The gene discussed is SLC16A1; the disease is Cognitive impairment.