Importantly, RNF43 ranked fourth in mutational frequency to APC (58.2%; 128/220), TP53 (50.9%; 112/220), KRAS (46.4%; 102/220) and at comparable frequency with BRAF (3.6%; 8/220) suggesting an important role of this gene in Middle Eastern CRC. Here, RNF43 is linked to colorectal carcinoma.