RNF43 and colorectal carcinoma: We also found an association between RNF43 mutation and APC wildtype (p = 0.0079) as well as TP53 wildtype (p = 0.0341) CRC, with 76.9% (10/13) of RNF43 mutant CRCs being APC wildtype and TP53 wildtype (Table 3).