Study GSE44805 reports that SHC4 (Expression Ratio = 0.70, p-Value = 2.07E−03), SLC24A5 (Expression Ratio = 0.37, p-Value = 3.77E−03), TYR (Expression Ratio = 0.39, p-Value = 1.65E−08), and MC1R (Expression Ratio = 0.89, p-Value = 1.13E−02) are downregulated in melanoma skin relative to adjacent normal skin. The gene discussed is MC1R; the disease is melanoma.