MMP2 and hepatocellular carcinoma: In addition, Astragaloside IV and Curcumin down-regulated the expression of fibroblast growth factor 2, matrix metalloproteinase 2 (MMP2), vascular endothelial growth factor (VEGF), hepatocyte growth factor, and synergistically inhibited nude-mouse model of HCC tumor growth and angiogenesis [34].