ITPR1 and autonomic neuropathy: However, ITPR1 is also expressed in other central and peripheral neurons (Fig. 1) [16, 17], and, accordingly, we and others subsequently described ITPR1-IgG/anti-Sj antibodies also in patients with paraneoplastic and non-paraneoplastic (radiculo)neuropathy, autonomic neuropathy, myelopathy, possible brainstem encephalitis and encephalopathy with seizures [16, 18].