While this is the only detailed report on that association, neuropsychiatric symptoms have been described in a few further patient positive for serum ITPR1-IgG/anti-Sj, including dementia and encephalopathy [18], confusion [16], memory loss [16], insomnia, anxiety and depression [18], as well as temporal lobe atrophy [18] and suspected temporal lobe epilepsy [16]. This evidence concerns the gene ITPR1 and major depressive disorder.