In addition to providing a general overview of the clinical and paraclinical features and summarizing the current knowledge on the pathophysiology of this new disorder, we here specifically point to the association of serum ITPR1-IgG/anti-Sj with dementia and psychosis by reporting on a patient in whom these antibodies were associated with rapidly progressive, severe cognitive decline, mainly affecting memory, attention and executive functions, optic hallucinations and depression. This evidence concerns the gene ITPR1 and depressive disorder.