ITPR1 and autoimmune encephalitis: This highlights the importance of screening sera and CSF from patients with suspected autoimmune encephalitis by means of tissue-based assays in order to recognize reactivities that may prompt a second level screening for ITPR1 or other rarer antigens by means of antigen-specific assays, considering that many laboratories routinely use only commercial assays (blot or CBA) for the most common anti-neuronal and anti-glial antibodies.