However, the KLAA0319 gene demonstrated a biased expression in multiple brain tissues, and three of 12 SNPs with nominal significance in the validation phase among the UKB population whose cases were abnormal on all three phenotypes and controls were normal were located in the KIAA0319 gene, indicating a potential cross-ethnic association of KIAA0319 with depression-cognition-memory. This evidence concerns the gene KIAA0319 and major depressive disorder.