The CD4+ and CD8+ T cell infiltration into the stroma and tumor epithelium was further determined by CD4 and CD8 IHC staining (Fig. S6).CD8+ T cells were further designated as CD8 TEM, CD8 TEMRA/TEFF, CD8 TRM, CD8 Naïve, CD8 IFN response, and CD8 Cycling cell subtypes, according to their marker genes (Fig. S7a, S7b). This evidence concerns the gene CD4 and neoplasm.