In cisplatin-resistant gastric cancer cells, interleukin-6 promoted the expression of SNHG3, which was positively correlated with drug resistance and “stemness” (partially manifested by overexpression of OCT4 and other stem cell markers), and the expression of OCT4 was significantly downregulated when SNHG3 was knocked out [34]. The gene discussed is POU5F1; the disease is gastric cancer.