The primary mechanism of action of cetuximab is the blockade of ligand-induced EGFR activation and downstream signaling, including signaling through the PI3K/Akt and MAPK/Erk pathways which have been linked to many processes crucial to tumor progression, including metastasis and cell survival, proliferation, adhesion, differentiation, migration, transformation, and motility36. Here, AKT1 is linked to neoplasm.