We observed altered expression in the constructed network and its effector proteins in NASH hepatic tissues, accompanied by a highly significant increase in the expression of (FOXA2, TEAD2 mRNAs, miR-650), proteins (IL-6 and TGF-β) and downregulation of LATS2 mRNA and RPARP AS-1 LncRNA. Here, FOXA2 is linked to metabolic dysfunction-associated steatohepatitis.