We used in silico analysis to construct a genetic (FOXA2, TEAD2, LATS2) and epigenetic network (miR-650 and RPARP AS-1 LncRNA) linked to the stimulation of hedgehog and hippo signaling with subsequent activation of HSCs and its effector proteins (L-6, and TGF-β) in NAFLD/NASH. The gene discussed is PTGDR; the disease is metabolic dysfunction-associated steatotic liver disease.