TGFB1 and metabolic dysfunction-associated steatohepatitis: For example, 12-week NASH group animals showed approximately 4- and 3.6-fold increases in IL6 and TGF-β concentrations, respectively (p < 0.01); similar 3.6- and 3-fold increases were seen in IL6 and TGF-β concentration in the 9-week NASH rats, respectively (p < 0.01).