Probiotic administration eliminated the effects of NASH on expression of FOXA2, TEAD2, LATS2 mRNAs, miR650, and RPARP AS-1 LncRNA; In 3- and 12-week treated group animals showed a significant decrease in RQ expression of FOXA2, TEAD2 mRNAs and miR-650 (p < 0.01), with a significant increase in RQ expression of LATS2 mRNA and RPARP AS-1 LncRNA (p < 0.01) when compared to 12-week NASH groups rats (Fig. 7). The gene discussed is PTGDR; the disease is metabolic dysfunction-associated steatohepatitis.