Moreover, EZH2 was associated with the malignant transformation of oral leukoplakia, and the latest research suggested that EZH2 could be targeted by the long noncoding RNA, RC3H2, which could be a complementary endogenous RNA sponging miR-101-3p that further facilitates cell proliferation and invasion in oral squamous cell carcinoma [17, 18]. This evidence concerns the gene EZH2 and oral cavity squamous cell carcinoma.