Additionally, mild CCF-mediated PPT can efficiently remodel the immunosuppressive microenvironment of HCC by inducing ICD and TIL infiltration, which amplifies aPD-L1 immunotherapy and genetic NR2F6 ablation and further prevents CTLs from adopting a dysfunctional/exhausted phenotype. Here, NR2F6 is linked to hepatocellular carcinoma.