In summary, we showed that the treatment of cells with IONPs and IOHNPs decreases SARS-CoV-2 production, affects the regulation of cellular iron metabolism in the cells, and that treatment of SARS-CoV-2 infected cells with FAC, Venofer or IONPs could counteract the transcription of FPN1, DMT1 and IREB2 induced by the virus, which could be a factor that prevents the correct replication of the virus after infection of Vero E6 cells. Here, IREB2 is linked to infection.