To determine the signaling pathway related to the regulation of CRC cell growth mediated by SLC6A14, several Cell Signaling Technology Pathway Antibody Sampler Kits (CST, MA, USA) were used to compare the activities of common cancer-related cell signaling pathways between the SLC6A14 knockdown and control cells, including the p38/MAPK signaling pathway, Notch activated signaling pathway, mTOR signaling pathway, and matrix remodeling. This evidence concerns the gene MTOR and cancer.