MCAT and colorectal carcinoma: As a result, we are the first to find that 16 of the 20 amino acids were increased in the supernate of HCT116 cells after silencing of SLC6A14 with siRNA or blockade with α-MT, demonstrating an important role of SLC6A14 in the regulation of amino acid uptake in CRC cells, which are essential for cancer cell proliferation.