Although a modest increase in viral entry was observed with higher levels of CD147, and although its upregulation was observed in obesity and diabetes [49], which are potential risk factors for severe COVID-19, the role of CD147 in SARS-CoV-2 infection has been disputed on the basis of the inability of CD147 to bind the S protein [50]. This evidence concerns the gene BSG and obesity due to melanocortin 4 receptor deficiency.