DEPDC5 and familial focal epilepsy with variable foci: To date, variants in the DEPDC5 have been proved to be main cause of various dominant familial focal epilepsies, such as autosomal dominant sleep-related hypermotor epilepsy, familial focal epilepsy with variable foci (FFEVF), familial temporal lobe epilepsy and focal epilepsy caused by various cortical developmental malformations [4].