Interestingly, Yao et al. in their work observed that PRKACB is down regulated in patients with stage III-IV colorectal cancer (HR = 2.931 (1.357-6.333), log-rank P = 0.0145), but not identified as risk factors for patients with stage I-II colorectal cancer (P > 0.05). This evidence concerns the gene PRKACB and colorectal cancer.