During sepsis, decreased PPAR \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha$$\end{document}α levels enforce an excess of free fatty acids, leading to disturbed lipid metabolism and lipotoxicity due to alterations in ß-oxidation (Wyngene et al. 2020). The gene discussed is PPARA; the disease is Sepsis.