Each 15 mL/min/1.73 m2 lower mean estimated glomerular filtration rate (GFR) has been shown to be associated with a 23% higher baseline hs-cTnT and 9% steeper increase in hs-cTnT in stable Chronic renal disease (CRD) stage 4–5 patients [23]. This evidence concerns the gene TNNT2 and chronic kidney disease.