CD59 is a complement regulatory protein that protects self-cells from complement mediated damage by specifically inhibiting membrane attack complex (MAC) formation [4]. In diabetes mellitus (DM), the complement regulatory function of CD59 is inhibited by the non-enzymatic glycation of the Lys41 amino acid residue forming a functionally inactive plasma glycated CD59 (pGCD59) leading to increased MAC deposition and cell damage. Here, CD59 is linked to diabetes mellitus.