Conversely, the protein expression of p300, FOXO3, and Sirt1 in IVD tissues of IDD rats in the presence of oe‐p300 + DMSO was notably higher than that in those in the presence of oe‐NC + DMSO (Figure 7b, Figure S3f). The gene discussed is SIRT1; the disease is intervertebral disk degenerative disorder.