The Pfirrmann score was diminished in IDD rats in the presence of oe‐p300 alone, while IDD rats treated with oe‐p300 + Wnt/β‐catenin agonist 1 or oe‐p300 + CQ demonstrated higher Pfirrmann grading in comparison with the oe‐p300‐treated IDD rats (Figure 7d, Figure S4). Here, EP300 is linked to intervertebral disk degenerative disorder.