Indeed, the miR‐182‐5p/Sirt1 axis could alleviate IDD through regulation of mitophagy and apoptosis (Xie et al., 2019), whereas conversely, the depletion of Sirt1 due by miR‐141 treatment promoted IDD by inducing the apoptosis of NPCs (Ji et al., 2018). Here, SIRT1 is linked to intervertebral disk degenerative disorder.