When we analysed the relationship between karyotype, menstrual pattern, GH and EPs therapy with comorbid conditions, we found that patients with karyotype 45,X were more likely to have hypertension, while those with mosaic 45,X/46,XX or 45,X/46,XY were less likely to have it (χ2 = 13.6, p = 0.009) (Table 5). Here, GH1 is linked to hypertensive disorder.