Second, there could be a potential susceptibility of animal carrying at least one allele A to an infection caused by virus genotypes B and E. Lastly, SRLV genotype B includes a B2 subtype which was associated to VM in sheep and is widely distributed in Italian, French, and Spanish sheep flocks, suggesting a limited impact of the SRLV genetic control program based on TMEM154 [32, 33]. The gene discussed is TMEM154; the disease is infection.