LMNA and limb-girdle muscular dystrophy: Progerin is the same as several other pathological changes associated with nuclear membrane protein gene defects, including Emery-Dreifuss muscular dystrophy, limb-Girdle muscular dystrophy, and congenital muscular dystrophy, which can lead to severe muscle pathology similar to muscle weakness in the elderly, suggesting that modification on the nuclear membrane may alter the development and function of skeletal muscle cells [50].