Though components of the spliceosome are recurrently mutated in hematologic malignancies [14], including the SF3B1 mutation present in approximately 10% of chronic lymphocytic leukemia and DDX41 mutation in follicular lymphoma and Hodgkin lymphoma, the biological function and oncogenic potential of alternative splicing have not been well studied [38]. Here, DDX41 is linked to Hodgkins lymphoma.