Given that the control group in both phases were the same, alteration in the T2D group and coexisting group illustrated that the mRNA level of AKT2, IL6, IL12B, IRS1, IRS2, MAPK14, and NFKB1 were higher in T2D + CHD patients compared to T2D patients. The gene discussed is IRS1; the disease is coronary artery disorder.