Toward this end, the overlapped up-regulated genes were mainly enriched in glucose and insulin-related biological processes such as positive regulation of glucose import, glucose metabolic process, cellular response to insulin stimulus, insulin receptor signaling pathway, positive regulation of glucose metabolic process, positive regulation of glucose import in response to insulin stimulus, etc. which indicated that the mechanism for CHD progression in diabetic patients might relate to the dysfunction of the above biological process. The gene discussed is INSR; the disease is coronary artery disorder.