Furthermore, more analysis revealed that some of these up-regulated genes dramatically increased or decreased in T2D plus CHD group compared to T2D only groups, such as FOXP3 and AQP2 decreased 170 and 57 times, respectively, or AKT2 and IRS1 increased more than 20 times compared to T2D group. Here, AQP2 is linked to type 2 diabetes mellitus.