IRF5 and hydrops fetalis: Yang [44] found one type of 110-KDa EVs in the HF of E. granulosus containing 25 miRNAs, which were internalised by sheep peripheral blood mononuclear cells in a time-dependent manner to upregulate IL-10, TNF-α and IRF5, and downregulate IL-1β, IL-17 and CD14.