Also, given the significant decrease in AUC of plasma insulin and the observed threefold increase in insulin sensitivity, it is likely that (at least in the short term) an exogenously imposed increase in GLP-1 activity does not result in obvious adverse metabolic effects (particularly exacerbation of hyperinsulinemia) at least in mixed cohort of normal horses and horses with mild ID. Here, INS is linked to Hyperinsulinemia.