demonstrated that Nrf2 targets like HO-1 and NQO1 suppressed the anti-apoptotic Bcl-2a and Bcl-2b genes, which increased drug resistance to imatinib and reduced apoptosis in K-562 and KU-812 human CML cell lines [176]. Here, NFE2L2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.