Ubiquitin-Protein Ligase E3 Synoviolin (also known as HMG-CoA reductase degradation protein 1 (Hrd1)) is a crucial ubiquitin ligase in the endoplasmic reticulum (ER) that is known as a regulator of Nrf2 in cirrhosis. The gene discussed is SYVN1; the disease is Cirrhosis.