Of note, accumulation of insoluble cytoplasmic TDP-43 (the histopathological hallmark of amyotrophic lateral sclerosis) was also described in a post mortem case of SPG11 [35], and the clinical overlap of SPG11 with amyotrophic lateral sclerosis has been described before [7]. Here, SPG11 is linked to amyotrophic lateral sclerosis.