The chromatin immunoprecipitation (CHIP)-qPCR assay indicated CBP (CREB-binding protein) and P300 (histone acetyltransferase) individually and directly interact with the LINC00460 promoter, and CBP/P300 downregulation decreased LINC00460 amounts in ESCC cells. Here, CREBBP is linked to esophageal squamous cell carcinoma.