LINC00460 is generally upregulated in multiple tumor cells in comparison to that in control cells (Table 1), including bladder [13, 14], breast [15], cervical [16, 17], colon [18, 19], colorectal [10, 20–24], esophageal [25], gastric [26, 27], ovarian [28], lung [11, 29–31], pancreatic [32] and papillary thyroid cancers [33–35], as well as acute myeloid leukemia (AML) [36], glioma [37], head and neck squamous cell carcinoma (HNSCC) [38–42], hepatocellular carcinoma [43–45], laryngeal squamous cell carcinoma [46], meningioma [47], nasopharyngeal carcinoma [48] and osteosarcoma [49]. The gene discussed is LINC00460; the disease is head and neck squamous cell carcinoma.