Recently, LINC00460 was described for its critical role in controlling oncogenes [11, 13, 15, 19, 21–23, 33, 35, 36, 39, 42–45, 47, 49, 51, 53] and tumor suppressors [10], generally modulating the above mentioned cancer cell features (Fig. 1). This evidence concerns the gene LINC00460 and cancer.