Therefore, the purpose of the study was to investigate the attenuation effect of Potentilla chinensis aqueous extract on urinary bladder function in CYP-induced hemorrhagic cystitis in rat model, and thus to evaluate if Potentilla chinensis aqueous extract could be a valuable natural pharmacological agent in the treatment of urinary bladder dysfunction in patients after CYP-based therapy. The gene discussed is PPIG; the disease is hemorrhagic cystitis.