In this context, upregulated growth factors such as FGF7 and EGF, also described being expressed in SASP of senescent fibroblasts, in combination with CCL2, CCL7, CCL13, CXCL6 and CXCL12 might play an important role in cancer progression which is relevant in that neoplasms can occur as late effects after SM exposure (Poursaleh et al. 2012; Coppé et al. 2010; Steinritz 2016). This evidence concerns the gene CCL2 and neoplasm.