Increase of PI(3,4,5)P3 (Supplementary Fig. 4b), as well as accelerated AKT-NF-κB-p53 pathway activation (Supplementary Fig. 4c) were detected in pre-malignant T-cells of 4-month-old ORP4L KI mice, an age at which transformed T-cells were not yet detectable, indicating the PI(4)P transport and PI3K/AKT pathway activation upon ORP4L expression in T-cells occur early during leukemia development, before emergence of the actual pathology. The gene discussed is TP53; the disease is leukemia.