Pregnant KIR2DL1-expressing females from the KIR × C*05 mating did not show evidence of hypertension throughout the course of gestation and post-partum (Supplementary Fig. 2a) or of proteinuria (Supplementary Fig. 2b), both hallmarks of pre-eclampsia18. The gene discussed is KIR2DL1; the disease is hypertensive disorder.