Therefore, in this study, the ANRIL level of clinical plasma samples was measured to evaluate its role in endothelial injury of CKD, and we found that ANRIL was increased in the plasma of CKD patients and negatively correlated with FMD, suggesting that ANRIL was associated with endothelial dysfunction in CKD. The gene discussed is CDKN2B-AS1; the disease is endothelial dysfunction.