In summary, we propose a model (Fig. 7) in which the observed reduction of miR-184-3p and consequent upregulation of its target gene CRTC1 in pancreatic islets from T2D donors follow the reduction/translocation of NKX6.1 observed in dedifferentiated and/or dysfunctional β-cells in T2D. This evidence concerns the gene NKX6-1 and type 2 diabetes mellitus.