Along with this process, activation of intrinsic signaling pathways especially cGAS-STING signaling, secretion of chemokines and cytokines (Table 1), formation of hypoxia condition, and activation of the classical and alternative complement system play a crucial role in reprogramming tumor microenvironment induced by IR.308–312 The process of reprogramming the tumor microenvironment is suffused with complex and profound changes, which is not only limited to a change in quantity and form, but also full of various interactions and modulations. This evidence concerns the gene CGAS and neoplasm.