On the contrary, IFN-β polarizes neutrophils to an antitumorigenic phenotype (N1) while inhibits N2 polarization.185 The function of N1 involves in promoting tumor cell cytotoxicity/apoptosis, strengthening the antibody-dependent cellular cytotoxicity (ADCC), and activating T cells.186–189 N2 phenotype shows the protumorigenic characteristics including promoting the tumor growth, stemness, angiogenesis, invasion, and suppressing immunity.190,191 However, to date our knowledge on the role of N1 and N2 in RT responses remains limited and contradictory. Here, IFNB1 is linked to neoplasm.