Besides, low-dose RT can reprogram the tumor microenvironment by increasing T cells, NK cells, polarizing M1 macrophage, upregulating immunostimulatory factors such as NKG2D and its ligand and downregulating inhibitory factor.342,348 Figuratively speaking, abscopal effect of RT increases the number of soldiers (immune cells and effective molecules) but sometimes their force is insufficient to enter the city. The gene discussed is KLRK1; the disease is neoplasm.