Moreover, Herrera et al.348 found that low-dose RT reprogrammed the tumor microenvironment of tumors with scarce immune infiltration and elicited predominantly CD4+ cells with features of exhausted effector cytotoxic cells, with a subset expressing NKG2D and exhibiting proliferative capacity, as well as a unique subset of activated dendritic cells expressing the NKG2D ligand Rae1. Here, CD4 is linked to neoplasm.