CD8A and neoplasm: Achievement of abscopal effect depends on shared TAAs from an irradiated tumor recognized by other lesions, but it is precise because of the heterogeneity of tumors that not the entire cellular population can exert an effective immune response at these other lesions.390,391 Even for TAAs that could be recognized by entire cellular population, the immunosuppressive tumor microenvironment may be the barrier for CD8+ T cells to access the lesions.392 If we irradiate multiple lesions, or even all tumor lesions, it is possible to overcome these barriers to immune activation.