Type I IFNs induced by cGAS–STING pathway are immunomodulatory factors to destroy cancer cells as the essential link of innate and adaptive immune responses through DCs.121,122 Type I IFNs secreted by cancer cells can facilitate DCs maturation, increase DCs co-stimulatory molecule expression as well as enhancing DCs lymph-node migratory capacity. This evidence concerns the gene STING1 and cancer.