STING1 and neoplasm: Intriguingly, it is reported that activation of STING pathway can reprogram MDSCs into immunostimulatory cells.250 However, majority of studies showed that STING signaling pathway in the tumor microenvironment can inhibit the recruitment, differentiation, and function of MDSCs.100 Cheng et al. observed that the activation of STING signaling pathway by cGAMP may enhance the secretion of IFN-γ but decrease the number of MDSCs in vivo.251 Therefore, these studies suggest the suppression function of IR on MDSCs.