TGFB1 and neoplasm: The interaction between neutrophil polarization and tumor microenvironment has been well summarized but there are few studies focusing on the relationship between TANs polarization and IR.178–184 Generally, TGF-β, an immunosuppressive cytokine overexpressed by tumor cells, polarizes neutrophils to a protumorigenic phenotype (N2) and inhibits N1 phenotypic polarization.