We have already certified the changes of cytokines and chemokines including TNFα, IL-1, IL-6, MCP-1, IL-8 at irradiated sites34 and that IR forms inflammatory tumor microenvironment remodeling by tumur cells.95 However, little is known about the expression levels of these immunomodulatory factors in tissues distant from the irradiated zone. Here, TNF is linked to neoplasm.