For instance, calreticulin increased by RT acts as a pro-phagocytosis eat-me signal in opposition to CD47.265 Release of HMGB1 from tumor cells, via TLR4 activation, promotes antigen presentation by DCs.266 In addition, IR can strengthen tumor cross-presentation of DCs which may promote the activation and proliferation of T cells.267,268 The release of DAMPs and TAAs promotes DCs to migrate towards lymph nodes and further results in the emergence of systemic antitumor immune responses. This evidence concerns the gene CALR and neoplasm.