Thus, targeting neutrophils and their immunosuppressive effector molecules, TGFβ and nicotinamide phosphoribosyltransferase (NAMPT) might be crucial to reversing immunosuppression.198 Besides the pro-tumor characteristics, TANs also exhibit antitumor characteristics by inhibiting the growth of tumor cells, and interacting with other immune cells which is induced by RT. The gene discussed is TGFB1; the disease is neoplasm.