As one of the critical promoting factors of EMT, the turnover of Snail1 is tightly governed by several F-box proteins in some specific cancers, including β-TrCP [51, 52] and FBXO22 [53] in breast cancer cells, FBXL14 [54] and FBXO11 [55, 56] in both breast and colon cancer cells, FBXL5 [57, 58] in breast cancer, colon cancer, gastric cancer, and pancreatic cancer cells, FBXO31 [59] in gastric cancer cells, FBXO45 [60] in prostate cancer cells, and FBXO11 [56] and FBXW7 [61, 62] in lung cancer cells. The gene discussed is FBXO22; the disease is malignant colon neoplasm.