TACC2 and pulmonary emphysema: Mechanistically, cigarette smoke exposure increased the phosphorylation of TACC2 at Ser304/399 and triggered the interaction of TACC2 with FBXL7, which in turn promoted K48-linkage polyubiquitylation and degradation of TACC2, leading to the induction of DNA damage and apoptosis, which probably contributes to lung inflammation and emphysema [26].